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Pharmacology in Drug Discovery and Development : Understanding Drug Response
Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action.Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems.New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting “descriptive” data into “predictive” data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug–drug interactions, and two new chapters.The newly developed companion website hosts further educational resources to complement the book.As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.
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The Wolf : Culture, Nature, Heritage
New insights into the changing human attitudes towards wild nature through the depiction of wolves in human culture and heritage. Few animals arouse such strong opinion as the wolf.It occupies a contested, ambiguous, yet central role in human culture and heritage.It appears as both an inspirational emblem of the wild and an embodiment of evil.Offering a mirror to different human attitudes, beliefs, and values, the wolf is, arguably, the species that plays the greatest role in shaping our views on what nature is or should be. North America and, more recently, Europe have witnessed a remarkable return of the grey wolf (Canis lupus, and its close relative the Eurasian wolf, Canis lupus lupus) to eco-systems.The essays collected here explore aspects of this recovery, and consider the history, literature and myth surrounding this iconic species.There are chapters on wolf taxonomy, including the coywolf, the red wolf, and the many faces of the dingo.We also meet the Tasmanian wolf and encounter Nazi Werewolves from Outer Space.The book explores the challenges of separating fact from fiction and superstition, and our willingness to co-exist with large carnivores in the twenty-first century.Biologists, historians, anthropologists, cultural theorists, conservationists and museologists will all find riches in the detail presented in this wolf collection.
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Hypnotic Response
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First Response
From the bestselling author of the Spider Shepherd and Jack Nightingale series comes First Response, the utterly addictive new thriller by Stephen Leather.London is under siege. Nine men in suicide vests primed to explode hold hostages in nine different locations around the city, and are ready to die for their cause. Their mission: to force the government to release jihadist prisoners from Belmarsh Prison. Their deadline: 6 p.m. Today. But the bombers are cleanskins, terrorists with no obvious link to any group, and who do not appear on any anti-terror watch list.What has brought them together on this one day to act in this way?Mo Kamran is the Superintendent in charge of the Special Crime and Operations branch of the Met.As the disaster unfolds and the SAS, armed police, and other emergency services rush to the scenes, he is tasked with preventing the biggest terrorist outrage the capital has ever known. But nothing is what it seems. And only Kamran has the big picture. Will anyone believe him?A chillingly plausible and pulse-pounding depiction of how London might be held to ransom in a concerted terrorist attack: this is thriller writing at its very best.
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Lethal Response
Lethal Response follows the aftermath of an epic and bloody battle.Law enforcement headed by Major Paul Stafford, destroyed a huge drug smuggling and people trafficking ring, in an operation code named, TRASHED. Stafford's previous success in smashing international terrorist groups and criminal gangs have seen him and his crew seconded to Hampshire Constabulary. The police are jubilant; they feel they have gained the upper hand. But without evidence to charge anyone with the horrific murder of his long term sergeant and friend, and the cold blooded shooting of an innocent colleague, Stafford feels he's failed. He determines to do whatever it takes to hunt the killers down. Crime bosses are fighting back. Witnesses are being killed to stop them from testifying - Stafford's colleagues and friends continue to be targeted. Stafford is desperate to protect the people he cares about. And bring the crime lords and their hitmen to justice. Paul Stafford's kind of justice. LETHAL RESPONSE, a breathtaking story following on from the author's stunning debut novel, TRASHED.
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Panic Response
Panic Response
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The Contemplative Response : Leadership and ministry in a distracted culture
Following on from the success of The Contemplative Minister, Ian Cowley offers new insight and greater depth for church leaders in a distracted world.Ian emphasises that the true self finds peace in resting in the love of God.He addresses the compulsions of our consumerist culture and calls those in leadership to an inner life of truthfulness, self-knowledge and self-discipline.Praise for Ian's previous book: 'An immensely readable tour de force' Church Times
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Call and Response
'A terrific collection' Monica Ali, author of Brick Lane and Love MarriageA Most Anticipated Title for Oprah Daily, Essence, BuzzFeed, The Millions and Brittle PaperFull of heart and humour, Gothataone Moeng's first collection, set between the rural village of Serowe and the thrumming capital city of Gaborone, captures a chorus of voices from a country in flux. Meet a young woman who has worn the same mourning clothes for almost a year, and a teenage girl who shies away from the room where her once vibrant aunt lies dying.Elsewhere, watch as a younger sister hides her romantic exploits from her family while her older brother openly flaunts his infidelities, and a traveller returns home laden with confusion and shame. Moeng, part of a new generation of writers coming out of Africa whose work is exploding onto the literary scene, offers us an insight into communities, experiences and landscapes through these cinematic stories peopled with unforgettable female protagonists. 'A good short story is a bit of alchemy, showing us so much in so few pages.Gothataone Moeng's debut collection does this over and over.' Rumaan Alam, author of Leave the World Behind
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